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desvenlafaxine will enhance the level or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by up to 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive days instantly previous to